Gene Symbol | P3H1 |
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Entrez Gene | 64175 |
Alt Symbol | GROS1, LEPRE1, OI8 |
Species | Human |
Gene Type | protein-coding |
Description | prolyl 3-hydroxylase 1 |
Other Description | growth suppressor 1|leprecan|leucine proline-enriched proteoglycan (leprecan) 1|leucine- and proline-enriched proteoglycan 1|procollagen-proline 3-dioxygenase |
Swissprots | Q7KZR4 Q32P28 Q96SK8 Q9H6K3 Q96SN3 Q9HC87 Q96BR8 Q96SL5 Q9HC86 |
Accessions | CAI72109 EAX07142 EAX07143 EAX07144 EAX07145 Q32P28 AF097431 AAG31018 AF097432 AAG31019 AK025841 BAB15256 AK027648 BAB55264 AK027680 BAB55291 AK027697 BAB55305 AK075418 BAC11608 AK297980 BAG60290 AK300210 BAG61980 BC004160 BC015309 AAH15309 BC068461 BC091513 BC108311 AAI08312 BC143961 BC143962 BE675748 BT007039 AAP35688 CR749690 CAH18474 DC404420 R67284 XM_005271110 XP_005271167 XM_011541947 XP_011540249 XM_011541948 XP_011540250 XM_011541949 XP_011540251 XR_946739 NM_001146289 NP_001139761 NM_001243246 NP_001230175 NM_022356 NP_071751 |
Function | Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. {ECO:0000269|PubMed:10951563}. |
Subcellular Location | Isoform 1: Endoplasmic reticulum. |
Gros1 CRISPR/Cas9 KO Plasmid (h) - sc-418566 from Santa Cruz Biotechnology
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Gros1 HDR Plasmid (h) - sc-418566-HDR from Santa Cruz Biotechnology
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Gros1 Double Nickase Plasmid (h) - sc-418566-NIC from Santa Cruz Biotechnology
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Gros1 Double Nickase Plasmid (h2) - sc-418566-NIC-2 from Santa Cruz Biotechnology
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Gros1 CRISPR Activation Plasmid (h) - sc-418566-ACT from Santa Cruz Biotechnology
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Gros1 CRISPR Activation Plasmid (h2) - sc-418566-ACT-2 from Santa Cruz Biotechnology
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Gros1 Lentiviral Activation Particles (h) - sc-418566-LAC from Santa Cruz Biotechnology
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Gros1 Lentiviral Activation Particles (h2) - sc-418566-LAC-2 from Santa Cruz Biotechnology
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Gros1 siRNA (h) - sc-37433 from Santa Cruz Biotechnology
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Gros1 shRNA Plasmid (h) - sc-37433-SH from Santa Cruz Biotechnology
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Gros1 shRNA (h) Lentiviral Particles - sc-37433-V from Santa Cruz Biotechnology
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LEPRE1 RNAi - H00064175-R01 from Novus Biologicals
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MISSION® esiRNA - EHU145841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11649 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11649 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04611 from Sigma-Aldrich
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LEPRE1 siRNA (Human) - CRJ1953 from Cohesion Biosciences
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shRNA set against Human LEPRE1 (NM_022356.3) - SHH329631 from Creative biogene
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Human LEPRE1 siRNA - orb272454 from Biorbyt
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LEPRE1 shRNA Plasmid (Human) - CHJ1953 from Cohesion Biosciences
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LEPRE1 miRNA 3'UTR clone - MiUTR3H-11166 from Creative biogene
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LEPRE1 miRNA 3'UTR clone - MiUTR3H-11167 from Creative biogene
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