| Gene Symbol |
PLA2G4A
|
| Entrez Gene |
100033889
|
| Alt Symbol |
PLA2, PLA2G1B
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IVA (cytosolic, calcium-dependent)
|
| Other Description |
cPLA2|cytosolic phospholipase A2|phospholipase A2 group IVA|phospholipase A2, group IB (pancreas)
|
| Swissprots |
O77793
|
| Accessions |
O77793 AF092539 AAC61774 XM_005609738 XP_005609795 XM_005609739 XP_005609796 XM_005609740 XP_005609797 XM_005609741 XP_005609798 XM_005609742 XP_005609799 NM_001081843 NP_001075312
|
| Function |
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}.
|
| Top Pathways |
Glutamatergic synapse, Choline metabolism in cancer, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, VEGF signaling pathway
|