| Gene Symbol |
PDGFB
|
| Entrez Gene |
100135774
|
| Alt Symbol |
PDGF
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
platelet-derived growth factor beta polypeptide
|
| Other Description |
-
|
| Swissprots |
P12919
|
| Accessions |
EU314951 ABY47637 XM_003989270 XP_003989319 XM_006934047 XP_006934109 XM_006934048 XP_006934110 XM_006934049 XP_006934111 XM_006934050 XP_006934112 XM_006934051 XP_006934113 XM_006934052 XP_006934114
|
| Function |
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Note=Released by platelets upon wounding. {ECO:0000250}.
|
| Top Pathways |
Rap1 signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway
|