| Gene Symbol |
Tgfb1
|
| Entrez Gene |
100135628
|
| Alt Symbol |
TGF-beta
|
| Species |
Guinea Pig
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor, beta 1
|
| Other Description |
TGF-beta-1|transforming growth factor beta-1|transforming growth factor-beta
|
| Swissprots |
Q9R148 Q9QZB3 Q9Z1Y6
|
| Accessions |
Q9Z1Y6 AF169347 AAD49347 AF191297 AAF02780 NM_001173023 NP_001166494
|
| Function |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. {ECO:0000250|UniProtKB:P04202}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|