| Gene Symbol |
LONP2
|
| Entrez Gene |
83752
|
| Alt Symbol |
LONP, LONPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lon peptidase 2, peroxisomal
|
| Other Description |
lon protease 2|lon protease homolog 2, peroxisomal|lon protease-like protein 2|peroxisomal LON protease like|peroxisomal Lon protease homolog 2
|
| Swissprots |
Q86WA8 Q96K43 B7ZKL7 Q0D2H6 Q8N3B9 Q8NCE9
|
| Accessions |
EAW82723 EAW82724 EAW82725 Q86WA8 AJ548761 CAD68987 AK027544 BAG51340 AK027666 BAB55278 AK074775 BAC11201 AK090452 BAC03433 AK127125 BAG54439 AK130091 AK172790 BAD18769 AK294779 BAG57906 AL834201 CAD38889 BC002916 AAH02916 BC004234 AAH04234 BC093910 AAH93910 BC093912 AAH93912 BC110434 AAI10435 BC143246 AAI43247 BM782695 BQ189130 DC316485 DC393124 T67139 XM_011523371 XP_011521673 NM_001300948 NP_001287877 NM_031490 NP_113678
|
| Function |
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:22002062}.
|
| Subcellular Location |
Peroxisome matrix {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:22002062}.
|