| Gene Symbol |
Slc2a8
|
| Entrez Gene |
56017
|
| Alt Symbol |
D2Ertd44e, GLUT8, GlutX1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 2, (facilitated glucose transporter), member 8
|
| Other Description |
GLUT-8|glucose transporter X1|glucose transporter type 8|glucose transporter type X1|intestinal GLUT8 transporter|solute carrier family 2, facilitated glucose transporter member 8
|
| Swissprots |
Q5BKP8 Q9JJZ0 Q9JJP4 Q9JIF3
|
| Accessions |
CAC88690 EDL08590 EDL08591 Q9JIF3 AF232061 AAF78366 AJ245936 CAB75719 AK081806 BAC38338 AK141193 AK155792 AK170319 BAE41714 AK193167 AK199852 AK215919 AY856043 AAX51785 AY856044 AAX51786 AY856045 AAX51787 AY856046 AAX51788 BC021758 AAH21758 BC090993 AAH90993 Y17802 CAB89815 XR_374107 NM_019488 NP_062361
|
| Function |
Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane. {ECO:0000250}.
|
| Tissue Specificity |
Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle.
|