| Gene Symbol |
NR3C2
|
| Entrez Gene |
374131
|
| Alt Symbol |
MR
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 3, group C, member 2
|
| Other Description |
mineralocorticoid receptor|nuclear receptor subfamily 3 group C member 2
|
| Swissprots |
Q8QHI2
|
| Accessions |
Q8QHI2 AF468211 AAL77075 AJ394913 AM067064 BU114709 BU259382 BU376471 BU436920 CD738545 FJ808618 ACO37437 GU230774 ADB24782 NM_001159345 NP_001152817
|
| Function |
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding. {ECO:0000250}.
|