Gene Symbol | ALDH9A1 |
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Entrez Gene | 223 |
Alt Symbol | ALDH4, ALDH7, ALDH9, E3, TMABADH |
Species | Human |
Gene Type | protein-coding |
Description | aldehyde dehydrogenase 9 family, member A1 |
Other Description | 4-trimethylaminobutyraldehyde dehydrogenase|R-aminobutyraldehyde dehydrogenase|aldehyde dehydrogenase (NAD+)|aldehyde dehydrogenase E3 isozyme|aldehyde dehydrogenase family 9 member A1|gamma-aminobutyraldehyde dehydrogenase |
Swissprots | Q9NZT7 Q5VV90 B2R6X1 B4DXY7 P49189 Q6LCL1 |
Accessions | EAW90758 P49189 AF172093 AAF43600 AK293520 BAG57002 AK301767 BAG63226 AK302183 BAG63549 AK302191 BAG63554 AK302654 BAG63893 AK312751 BAG35618 BC011410 BC070030 BC151140 AAI51141 BC151141 AAI51142 U34252 AAB18827 U50203 AAB06721 X75425 CAA53176 XM_011509294 XP_011507596 NM_000696 NP_000687 |
Function | Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. {ECO:0000269|PubMed:10702312}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain. Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. {ECO:0000269|PubMed:8645224}. |
Top Pathways | Glycolysis / Gluconeogenesis, Tryptophan metabolism, Fatty acid degradation, Pyruvate metabolism, Glycerolipid metabolism |
ALDH9A1 CRISPR/Cas9 KO Plasmid (h) - sc-409588 from Santa Cruz Biotechnology
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ALDH9A1 HDR Plasmid (h) - sc-409588-HDR from Santa Cruz Biotechnology
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ALDH9A1 Double Nickase Plasmid (h) - sc-409588-NIC from Santa Cruz Biotechnology
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ALDH9A1 Double Nickase Plasmid (h2) - sc-409588-NIC-2 from Santa Cruz Biotechnology
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ALDH9A1 CRISPR Activation Plasmid (h) - sc-409588-ACT from Santa Cruz Biotechnology
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ALDH9A1 CRISPR Activation Plasmid (h2) - sc-409588-ACT-2 from Santa Cruz Biotechnology
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ALDH9A1 Lentiviral Activation Particles (h) - sc-409588-LAC from Santa Cruz Biotechnology
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ALDH9A1 Lentiviral Activation Particles (h2) - sc-409588-LAC-2 from Santa Cruz Biotechnology
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ALDH9A1 siRNA (h) - sc-88344 from Santa Cruz Biotechnology
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ALDH9A1 shRNA Plasmid (h) - sc-88344-SH from Santa Cruz Biotechnology
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ALDH9A1 shRNA (h) Lentiviral Particles - sc-88344-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU069511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1784 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1784 from Sigma-Aldrich
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ALDH9A1 siRNA (Human) - CRH0158 from Cohesion Biosciences
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ALDH9A1 RNAi - H00000223-R01 from Novus Biologicals
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ALDH9A1 - MBS8237109 from MyBioSource
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shRNA set against Human ALDH9A1 (NM_000696.3) - SHH234986 from Creative biogene
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shRNA set against Human ALDH9A1(NM_000696.3) - SHG053197 from Creative biogene
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ALDH9A1 shRNA Plasmid (Human) - CHH0158 from Cohesion Biosciences
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ALDH9A1 miRNA 3'UTR clone - MiUTR1H-00295 from Creative biogene
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