| Gene Symbol |
HDAC10
|
| Entrez Gene |
83933
|
| Alt Symbol |
HD10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 10
|
| Other Description |
-
|
| Swissprots |
Q9UGX2 Q6STF9 Q969S8 Q9UGX1 Q96P78 Q9H028 Q96P77 Q08AP4
|
| Accessions |
EAW73511 EAW73512 EAW73513 EAW73514 EAW73515 EAW73516 EAW73517 EAW73518 EAW73519 EAW73520 Q969S8 AF393962 AAK84023 AF407272 AAK92205 AF407273 AAK92206 AF426160 AAL30513 AL512711 CAC21653 AY450395 AAS48345 BC032049 BC032423 BC094734 BC125082 AAI25083 BC125083 AAI25084 BI916349 BM983038 CA424576 CR456465 CAG30351 CU013015 CAK54446 CU013303 CAK54745 NM_001159286 NP_001152758 NM_032019 NP_114408
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Excluded from the nucleoli.
|
| Tissue Specificity |
Ubiquitous. High expression in liver, spleen, pancreas and kidney.
|
| Top Pathways |
Viral carcinogenesis, Alcoholism
|
![Western Blot: HDAC10 Overexpression Lysate (Adult Normal) [NBL1-11478] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HDAC10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9643_HDAC10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11478-img0002.jpg)