| Gene Symbol | IL4 |
|---|---|
| Entrez Gene | 403785 |
| Alt Symbol | IL-4 |
| Species | Dog |
| Gene Type | protein-coding |
| Description | interleukin 4 |
| Other Description | B-cell stimulatory factor 1|BSF-1|interleukin-4|lymphocyte stimulatory factor 1 |
| Swissprots | O77762 A1E293 |
| Accessions | O77762 AF054833 AAD11563 AF072696 AAD51860 AF083270 AAD09005 AF091132 AAD46990 AF104245 AAC83931 AF187322 AAF01043 AF239917 AAF60177 AF328928 AAL26922 EF095771 ABL01502 NM_001003159 NP_001003159 |
| Function | Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Top Pathways | Inflammatory bowel disease (IBD), Measles, PI3K-Akt signaling pathway, Leishmaniasis, Cytokine-cytokine receptor interaction |