PSMB9
| Gene Symbol | PSMB9 |
|---|---|
| Entrez Gene | 5698 |
| Alt Symbol | LMP2, PSMB6i, RING12, beta1i |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, beta type, 9 |
| Other Description | large multifunctional peptidase 2|low molecular mass protein 2|macropain chain 7|multicatalytic endopeptidase complex chain 7|proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)|proteasome catalytic subunit 1i|proteasome chain 7|proteasome subunit beta 6i|proteasome subunit beta type-9|proteasome subunit beta-1i|proteasome-related gene 2|really interesting new gene 12 protein |
| Swissprots | P28065 Q5JNW4 B0V0T1 Q16523 |
| Accessions | AHW47927 AHW47944 AHW47961 AHW47978 CAA47024 CAA60784 CAA78700 EAX03653 EAX03654 P28065 AI310206 AK303118 BAG64224 BC065513 AAH65513 BF513693 BI832878 BM998687 BX641100 CR541656 CAG46457 S75169 AAC60646 U01025 AAC50154 X62741 CAA44603 XM_011546317 XP_011544619 XM_011548065 XP_011546367 XM_011548455 XP_011546757 NM_002800 NP_002791 NM_148954 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. {ECO:0000269|PubMed:8163024}. |
| Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}. |
| Top Pathways | Proteasome |
LMP2 CRISPR/Cas9 KO Plasmid (h) - sc-401615 from Santa Cruz Biotechnology
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LMP2 HDR Plasmid (h) - sc-401615-HDR from Santa Cruz Biotechnology
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LMP2 Double Nickase Plasmid (h) - sc-401615-NIC from Santa Cruz Biotechnology
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LMP2 Double Nickase Plasmid (h2) - sc-401615-NIC-2 from Santa Cruz Biotechnology
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LMP2 CRISPR Activation Plasmid (h) - sc-401615-ACT from Santa Cruz Biotechnology
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LMP2 CRISPR Activation Plasmid (h2) - sc-401615-ACT-2 from Santa Cruz Biotechnology
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LMP2 Lentiviral Activation Particles (h) - sc-401615-LAC from Santa Cruz Biotechnology
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LMP2 Lentiviral Activation Particles (h2) - sc-401615-LAC-2 from Santa Cruz Biotechnology
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LMP2 siRNA (h) - sc-35820 from Santa Cruz Biotechnology
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LMP2 shRNA Plasmid (h) - sc-35820-SH from Santa Cruz Biotechnology
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LMP2 shRNA (h) Lentiviral Particles - sc-35820-V from Santa Cruz Biotechnology
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LMP2/PSMB9 RNAi - H00005698-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17606 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17606 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01983 from Sigma-Aldrich
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PSMB9 siRNA (Human) - CRH3845 from Cohesion Biosciences
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LMP2/PSMB9 RNAi - H00005698-R02 from Novus Biologicals
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shRNA set against Human PSMB9 (NM_002800.4) - SHH385252 from Creative biogene
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shRNA set against Human PSMB9(NM_002800.4) - SHR147660 from Creative biogene
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PSMB9 shRNA Plasmid (Human) - CHH3845 from Cohesion Biosciences
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PSMB9 miRNA 3'UTR clone - MiUTR1H-08383 from Creative biogene
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