| Gene Symbol | URGCP |
|---|---|
| Entrez Gene | 55665 |
| Alt Symbol | URG4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | upregulator of cell proliferation |
| Other Description | HBV X protein up-regulated gene 4 protein|HBxAg up-regulated gene 4 protein|up-regulated gene 4|up-regulator of cell proliferation |
| Swissprots | Q9NWR7 Q9P221 E9PFF6 Q68DH6 Q8WV98 Q658M4 Q6MZZ5 Q8TCY9 |
| Accessions | EAW94174 EAW94175 EAW94176 Q8TCY9 AB040940 BAA96031 AK000661 BAA91312 AK026185 AK302459 BAH13717 AK314339 BAG36982 AL832134 AL833744 CAH56246 AY078404 AAL83710 BC018426 AAH18426 BG722670 BX640797 CAE45880 BX648505 CD628752 CR749398 CAH18244 DA240479 DA316326 DA494692 DC336174 DQ891074 ABM82000 DQ894257 ABM85183 DR421788 NM_001077663 NP_001071131 NM_001077664 NP_001071132 NM_001290075 NP_001277004 NM_001290076 NP_001277005 NM_017920 NP_060390 |
| Function | May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. Nucleus {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. |
| Tissue Specificity | Strongly expressed in hepatitis B virus- infected liver and in HCC cells. Also highly expressed in well- differentiated gastric cancer tissues and various gastric cancer cell lines. {ECO:0000269|PubMed:12082552, ECO:0000269|PubMed:17217616}. |
URG4 CRISPR/Cas9 KO Plasmid (h) - sc-412570 from Santa Cruz Biotechnology
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URG4 HDR Plasmid (h) - sc-412570-HDR from Santa Cruz Biotechnology
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URG4 Double Nickase Plasmid (h) - sc-412570-NIC from Santa Cruz Biotechnology
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URG4 Double Nickase Plasmid (h2) - sc-412570-NIC-2 from Santa Cruz Biotechnology
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URG4 CRISPR Activation Plasmid (h) - sc-412570-ACT from Santa Cruz Biotechnology
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URG4 CRISPR Activation Plasmid (h2) - sc-412570-ACT-2 from Santa Cruz Biotechnology
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URG4 Lentiviral Activation Particles (h) - sc-412570-LAC from Santa Cruz Biotechnology
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URG4 Lentiviral Activation Particles (h2) - sc-412570-LAC-2 from Santa Cruz Biotechnology
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URG4 siRNA (h) - sc-89691 from Santa Cruz Biotechnology
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URG4 shRNA Plasmid (h) - sc-89691-SH from Santa Cruz Biotechnology
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URG4 shRNA (h) Lentiviral Particles - sc-89691-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22541 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06416 from Sigma-Aldrich
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URGCP siRNA (Human) - CRJ0817 from Cohesion Biosciences
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URGCP - MBS8235418 from MyBioSource
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shRNA set against Human URGCP (NM_017920.3) - SHH441024 from Creative biogene
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shRNA set against Human URG4(NM_001077663.1) - SHL116222 from Creative biogene
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shRNA set against Human URG4(NM_017920.3) - SHL116234 from Creative biogene
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shRNA set against Human URG4(NM_001077663.1) - SHL116352 from Creative biogene
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shRNA set against Human URG4(NM_017920.3) - SHL116358 from Creative biogene
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shRNA set against Human URG4(NM_001077664.1) - SHL116382 from Creative biogene
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Human URGCP siRNA - orb271318 from Biorbyt
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URGCP shRNA Plasmid (Human) - CHJ0817 from Cohesion Biosciences
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