| Gene Symbol |
HTR1B
|
| Entrez Gene |
100144391
|
| Alt Symbol |
-
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
|
| Other Description |
5-HT-1B|5-HT1B|5-hydroxytryptamine receptor 1B|serotonin receptor 1B
|
| Swissprots |
Q588Y6
|
| Accessions |
Q588Y6 AB190344 BAD93295 NM_001122872 NP_001116344
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|