| Gene Symbol |
SRSF7
|
| Entrez Gene |
6432
|
| Alt Symbol |
9G8, AAG3, SFRS7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serine/arginine-rich splicing factor 7
|
| Other Description |
SR splicing factor 7|aging-associated protein 3|splicing factor 9G8|splicing factor, arginine/serine-rich 7, 35kDa
|
| Swissprots |
Q564D3 G5E9M3 B4DLU6 Q16629
|
| Accessions |
AAA88098 AAX93102 CAH05543 EAX00363 EAX00364 EAX00365 EAX00366 Q16629 AB445102 BAI99737 AF055270 AAF00003 AK091425 BAC03661 AK225141 AK293667 BAG57113 AK297161 BAG59658 AY166860 AAN87842 AY513287 AAT08040 BC000997 AAH00997 BC017369 AAH17369 BC017908 AAH17908 BC022328 AAH22328 BT006745 AAP35391 DC358626 L22253 AAA35495 XM_005264484 XP_005264541 XM_005264485 XP_005264542 XM_011533032 XP_011531334 XR_426994 XR_939708 XR_939709 XR_939710 XR_939711 NM_001031684 NP_001026854 NM_001195446 NP_001182375 NM_006276
|
| Function |
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11336712}. Cytoplasm {ECO:0000269|PubMed:11336712}.
|
| Tissue Specificity |
Brain, liver, kidney and lung.
|
| Top Pathways |
Spliceosome, Herpes simplex infection
|