Gene Symbol |
INTS7
|
Entrez Gene |
25896
|
Alt Symbol |
C1orf73, INT7
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
integrator complex subunit 7
|
Other Description |
-
|
Swissprots |
Q9NVH2 Q9UFC6 Q9H9V3 B7WPB6 Q9NVU5 Q8N4K7 B4DLZ6 Q8WUH5 Q9UFM3 B7WNP6
|
Accessions |
EAW93400 EAW93401 EAW93402 EAW93403 EAW93404 EAW93405 EAW93406 Q9NVH2 AK001363 BAA91650 AK001598 BAA91779 AK022509 BAB14067 AK022589 BAB14116 AK297225 BAG59708 AL117576 CAB56000 AL133049 CAB61376 AM392654 CAL37532 BC009918 BC020523 AAH20523 BC030716 AAH30716 BC033918 AAH33918 BC036009 BK005725 DAA05725 DB062625 XM_011509396 XP_011507698 XM_011509397 XP_011507699 NM_001199809 NP_001186738 NM_001199811 NP_001186740 NM_001199812 NP_001186741 NM_015434 NP_056249 NR_037667
|
Function |
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. {ECO:0000269|PubMed:21659603}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:21659603}. Chromosome {ECO:0000269|PubMed:21659603}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.
|