| Gene Symbol |
GNB2L1
|
| Entrez Gene |
397605
|
| Alt Symbol |
-
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
|
| Other Description |
G-beta like protein|RACK1|guanine nucleotide-binding protein subunit beta-2-like 1|receptor for activated C kinase|receptor of activated protein kinase C 1
|
| Swissprots |
P63246
|
| Accessions |
AAD37978 P63246 AK237420 AK237743 AK239515 AK239567 AK239961 AK345704 AK347796 AK351147 Z33879 CAA83944 XM_005658237 XP_005658294 NM_214332 NP_999497
|
| Function |
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Differentially expressed in various tissues, with highest expression observed in thymus, pituitary, spleen and liver, whereas there was no detectable expression in muscle. {ECO:0000269|PubMed:10673032}.
|
| Top Pathways |
Measles
|