| Gene Symbol |
St3gal2
|
| Entrez Gene |
20444
|
| Alt Symbol |
AI429591, AW822065, ST3GalII, Siat5
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
|
| Other Description |
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2|SIAT4-B|ST3Gal II|ST3GalA.2|alpha 2,3-ST 2|beta-galactoside alpha-2,3-sialyltransferase 2|gal-NAc6S|gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|sialyltransferase 4B|sialyltransferase 5
|
| Swissprots |
Q11204 Q8BPL0
|
| Accessions |
EDL11477 EDL11478 Q11204 AK029246 AK031052 AK034554 BAC28752 AK034863 BAC28859 AK037177 AK053827 BAC35543 AK131653 BAE20742 AK134937 BAE22346 BC015264 AAH15264 BC066064 AAH66064 BY582241 CJ174248 X76989 CAA54294 XM_006530786 XP_006530849 XM_006530787 XP_006530850 XM_006530788 XP_006530851 NM_009179 NP_033205
|
| Function |
It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
|
| Subcellular Location |
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
|
| Tissue Specificity |
Strongly expressed in brain and liver and to a lesser extent in heart and kidney. Scarcely detectable in lung, pancreas, spleen and submaxillary gland.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series
|