| Gene Symbol |
Irf7
|
| Entrez Gene |
54123
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interferon regulatory factor 7
|
| Other Description |
IRF-7
|
| Swissprots |
P70434
|
| Accessions |
EDL18024 EDL18025 EDL18026 EDL18027 EDL18028 EDL18029 EDL18030 EDL18031 P70434 AK002830 AK004349 AK079685 BAC37723 AK089869 AK150403 BAE29529 AK150608 BAE29699 AK151470 AK152401 BAE31189 AK152403 BAE31191 AK153054 BAE31680 AK155950 AK158378 AK158403 AK159142 AK159883 BAE35453 BC138799 AAI38800 BC145422 BQ033099 BY155234 DT923384 U73037 AAB18626 XM_006536214 XP_006536277 NM_001252600 NP_001239529 NM_001252601 NP_001239530 NM_016850 NP_058546
|
| Function |
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear locali
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15361868}. Cytoplasm {ECO:0000269|PubMed:15361868}. Note=The phosphorylated and active form accumulates selectively in the nucleus.
|
| Top Pathways |
Hepatitis C, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Measles, Influenza A
|
