| Gene Symbol |
PARK7
|
| Entrez Gene |
511268
|
| Alt Symbol |
DJ-1, DJ1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
parkinson protein 7
|
| Other Description |
Parkinson disease (autosomal recessive, early onset) 7|parkinson disease protein 7 homolog|protein DJ-1|protein deglycase DJ-1
|
| Swissprots |
Q3ZC96 Q5E946
|
| Accessions |
DAA21279 Q5E946 BC102707 BT021074 AAX09091 XM_005216955 XP_005217012 XM_005216956 XP_005217013 NM_001015572 NP_001015572
|
| Function |
Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Its involvement in protein repair could also explain other unre
|
| Subcellular Location |
Cell membrane {ECO:0000250|UniProtKB:O88767}; Lipid-anchor {ECO:0000250|UniProtKB:O88767}. Cytoplasm {ECO:0000250|UniProtKB:Q99497}. Nucleus {ECO:0000250|UniProtKB:Q99497}. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion {ECO:0000250|UniProtKB:Q99497}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000250|UniProtKB:Q99497}.
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