| Gene Symbol |
DOCK7
|
| Entrez Gene |
85440
|
| Alt Symbol |
EIEE23, ZIR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dedicator of cytokinesis 7
|
| Other Description |
dedicator of cytokinesis protein 7
|
| Swissprots |
Q5T1C0 Q96NG6 Q9C092 Q96NI0 Q96N67 Q45RE8 Q6ZV32 Q2PPY7 Q8TB82 Q45RE9 Q5T1B9 Q00M63
|
| Accessions |
EAX06582 Q96N67 AB051558 BAB21862 AK022097 AK055296 AK055401 BAB70917 AK055493 BAB70933 AK055905 BAB71042 AK091479 BAG52372 AK125049 BAC86032 AK292640 BAF85329 AK299737 BAG61632 BC016392 AAH16392 BC018075 BC018076 BC041813 BC112387 AAI12388 BC172250 AAI72250 BG190976 BG205481 BG207092 BU567903 BU943181 BX094950 BX485492 DQ118679 AAZ38451 DQ118680 AAZ38452 DQ309763 ABC33725 DQ341187 ABC68221 DR002667 XM_005271292 XP_005271349 XM_011542326 XP_011540628 XM_011542327 XP_011540629 XM_011542328 XP_011540630 XM_011542329 XP_011540631 XM_011542330 XP_011540632 NM_001271999 NP_001258928 NM_001272000 NP_001258929 NM_001272001 NP_001258930 NM_001272002 NP_001258931 NM_033407 NP_212132
|
| Function |
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419}.
|
| Subcellular Location |
Cell projection, axon {ECO:0000269|PubMed:16982419}. Note=Enriched in the developing axons of hippocampal neurons.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11214970}.
|