| Gene Symbol | HLA-DRB5 |
|---|---|
| Entrez Gene | 3127 |
| Alt Symbol | HLA-DRB |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class II, DR beta 5 |
| Other Description | DR beta-5|DR-9|DR2-beta-2|DR9|HLA class II histocompatibility antigen, DR beta 5 chain|HLA class II histocompatibility antigen, DR-5 beta chain|HLA class II histocompatibility antigen, DRB1-9 beta chain|MHC HLA-DR-beta cell surface glycoprotein|MHC HLA-DR-beta chain|MHC class II HLA beta chain|MHC class II antigen DRB1*9|MHC class II antigen DRB5|dw2|human leucocyte antigen DRB5|leukocyte antigen class II |
| Swissprots | Q9MY54 Q29787 C7C4X3 Q6SJR2 Q30126 Q9XRX6 Q30154 B2RBV6 O46700 Q8HWS7 Q29788 Q7M2H9 O00283 Q30199 Q29703 Q30150 O00157 Q8WLR5 |
| Accessions | AAA36292 AAA52325 AAA58651 AAA58657 AAA59693 AAA59791 AAA63193 AAA65914 AAA67471 AAA67957 AAA75451 AAA79206 AAA84388 AAA86242 AAA91838 AAA91841 AAA91847 AAB02172 AAB08109 AAB17276 AAB17994 AAB50934 AAB52229 AAB52232 AAB52235 AAB52236 AAB52237 AAB58397 AAB65751 AAB71649 AAB87709 AAB88297 AAC05828 AAC05839 AAC24013 AAC32201 AAC61746 AAD10735 AAD29582 AAD29583 AAD31286 AAD31289 AAD31295 AAD31309 AAD31310 AAD31766 AAD47814 AAD51315 AAD53053 AAF06175 AAF06176 AAF35306 AAF64297 AAF65490 AAF65491 AAF65492 AAF65494 AAF65495 AAF65500 AAF78946 AAF99607 AAF99608 AAG00414 AAG01005 AAG42258 AAG50193 AAK20872 AAK21117 AAL12226 AAL47161 AAN28924 AAN75784 AAN86038 AAO16556 AAO17056 AAO23237 AAO23238 AAO23239 AAO91660 AAP13509 AAP21612 AAP21614 AAP32697 AAP34691 AAP34695 AAP34697 AAP55804 AAP55805 AAP70485 AAP74221 AAP93590 AAQ85128 AAQ96776 AAR10879 AAR10882 AAR20446 AAR28667 AAR89455 AAR98643 AAR98644 AAS48869 AAT64904 AAT76040 AAT76041 AAV33684 AAV33685 AAV33686 AAV33687 AAV33688 AAV35213 AAW66688 AAW80834 AAW82335 AAZ53370 ABA06592 ABA06600 ABF60567 ABF74599 ABF93212 ABG25965 ABH05946 ABK56696 ABN58745 ABP38039 BAA02678 BAA03281 BAA06216 BAA08440 BAA36549 BAA36550 BAC66088 BAD02944 BAD15070 BAO73172 BAO73173 BAO73174 CAA45842 CAA45846 CAA45847 CAA46544 CAA60498 CAA61271 CAA64958 CAA65956 CAA68152 CAA68865 CAA70524 CAA74055 CAA76817 CAA76871 CAB05668 CAB11742 CAB51474 CAB51475 CAB53343 CAB53344 CAB53346 CAB56285 CAB65734 CAB71144 CAB94833 CAC06089 CAC10354 CAC19016 CAC19085 CAC29238 CAD36477 CAD44639 CAD44945 CAD45638 CAD45639 CAD47817 CAD55599 CAD59236 CAD62435 CAH04455 CAH69440 CAI05916 CAI29455 CAI38569 CAI47597 CAJ01187 CAJ29895 CAJ43899 CAJ76979 EAW50813 EAW50814 EAW50815 EAW50816 Q30154 Q9TQE0 AB062112 BAB84521 AF004817 AAB61608 AF097680 AF490771 AAO85467 AJ297582 CAC08822 AJ580838 CAE45568 AK292140 BAF84829 AK314834 BAG37353 BC009234 AAH09234 HQ447115 ADQ31602 M15992 AAA59678 M16086 AAA59679 M16954 AAA36276 M16955 AAA36277 M16956 AAA36278 M17377 AAA59818 M17379 AAA59803 M17382 AAA59819 M17383 AAA36294 M20429 AAA59822 M20503 AAA59826 M27689 AAA59829 M30181 AAA59840 M30182 AAA59715 M32578 AAA59795 M57648 AAA63218 M59798 AAA64236 S79786 AAD14315 U17381 AAC50167 U31770 AAB63983 U66826 AAD43829 U95818 AAD00818 X99895 CAA68170 XM_011514562 XP_011512864 NM_002125 NP_002116 |
| Function | Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173, ECO:0000305}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Top Pathways | Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection |