| Gene Symbol |
STAB2
|
| Entrez Gene |
55576
|
| Alt Symbol |
FEEL2, FELE-2, FELL2, FEX2, HARE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
stabilin 2
|
| Other Description |
CD44-like precursor FELL|FAS1 EGF-like and X-link domain containing adhesion molecule-2|fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-2|hepatic hyaluronan clearance receptor|hyaluronan receptor for endocytosis|hyaluronic acid receptor for endocytosis|stabilin-2
|
| Swissprots |
Q9H7H7 Q8TES1 Q8WWQ8 Q9NRY3 Q8IUG9 Q86UR4 Q7Z5N9 Q6ZMK2
|
| Accessions |
CCQ43556 EAW97711 EAW97712 EAW97713 EAW97714 Q8WWQ8 AB052958 BAC15608 AF160476 AAF82398 AJ295695 CAC82105 AK024503 BAB15793 AK074051 BAB84877 AK160380 BAD18723 AL133021 CAB61358 AY227444 AAO39681 AY311388 AAP74958 BC172224 AAI72224 XM_011538537 XP_011536839 XM_011538538 XP_011536840 XM_011538539 XP_011536841 XM_011538540 XP_011536842 XM_011538541 XP_011536843 XM_011538542 XP_011536844 XR_429107 XR_944609 NM_017564 NP_060034
|
| Function |
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS. {ECO:0000269|PubMed:12077138, E
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface.
|
| Tissue Specificity |
Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line. {ECO:0000269|PubMed:11829752, ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:12473645, ECO:0000269|PubMed:12626425, ECO:0000269|PubMed:17675564, ECO:0000269|PubMed:17962816}.
|