| Gene Symbol |
APP
|
| Entrez Gene |
351
|
| Alt Symbol |
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amyloid beta (A4) precursor protein
|
| Other Description |
alzheimer disease amyloid protein|amyloid beta A4 protein|beta-amyloid peptide|beta-amyloid peptide(1-40)|beta-amyloid peptide(1-42)|cerebral vascular amyloid peptide|peptidase nexin-II|preA4|protease nexin-II
|
| Swissprots |
B4DII8 Q16020 Q6GSC0 D3DSD1 Q9UQ58 P78438 Q9UCD1 Q9BT38 Q13764 D3DSD3 Q13793 P09000 Q9UCC8 Q16011 Q16019 Q9UCA9 Q9UC33 B2R5V1 Q16014 Q9UCB6 Q8WZ99 P05067 D3DSD2 Q13778
|
| Accessions |
AAA51727 AAA51768 AAB19991 AAB23645 AAB23646 AAB59501 AAB59502 AAC13654 AAC60601 AAG47389 AAW82435 AGD80371 AGD80372 AGD80373 BAA22264 CAA31830 CAJ84410 CAL33835 CAL69791 CAL69792 CAL69795 CAL69796 CAL69831 CAL69838 CCQ42932 EAX09957 EAX09958 EAX09959 EAX09960 EAX09961 EAX09962 EAX09963 EAX09964 EAX09965 EAX09966 P05067 A02759 CAA00268 AB066441 BAB71958 AF282245 AAQ14327 AK294534 BAG57741 AK295373 BAH12049 AK295621 BAG58500 AK296229 BAG58951 AK297229 BAG59712 AK297412 BAG59847 AK298861 BAG60983 AK311717 AK312326 BAG35248 BC004369 AAH04369 BC065523 BC065529 AAH65529 BE907745 BI559391 BM172428 BM876312 CB854706 DC336035 EU832797 ACE87808 GQ129348 ACT64482 M15532 AAA51564 M15533 AAA35540 M16765 AAA51722 M18734 AAA51726 M28373 AAA58727 M35675 AAA60163 S41243 S60721 AAB26263 S61380 AAB26264 S61383 AAB26265 X06981 CAA30041 X06982 CAA30042 X06989 CAA30050 Y00264 CAA68374 NM_000484 NP_000475 NM_001136016 NP_001129488 NM_001136129 NP_001129601 NM_001136130 NP_001129602 NM_001136131 NP_001129603 NM_001204301 NP_001191230 NM_001204302 NP_001191231 NM_001204303 NP_001191232 NM_201413 NP_958816 NM_201414 NP_958817
|
| Function |
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Note=Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly
|
| Tissue Specificity |
Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex- opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra- striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non- neuronal cells. Isoform APP751 is the most abundant form in T- lymphocytes. Appican is expressed in astrocytes. {ECO:0000269|PubMed:12859342, ECO:0000269|PubMed:1406936}.
|
| Top Pathways |
Alzheimer's disease
|
