| Gene Symbol |
ACKR1
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| Entrez Gene |
2532
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| Alt Symbol |
CCBP1, CD234, DARC, Dfy, FY, GPD, GpFy, WBCQ1
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| Species |
Human
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| Gene Type |
protein-coding
|
| Description |
atypical chemokine receptor 1 (Duffy blood group)
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| Other Description |
Duffy blood group antigen|Duffy blood group, atypical chemokine receptor|Duffy blood group, chemokine receptor|Fy glycoprotein|atypical chemokine receptor 1|glycoprotein D|plasmodium vivax receptor
|
| Swissprots |
A8YPG5 O75898 Q16570 Q16300 Q8WWE3 Q9UKZ5 Q9UKZ6 Q9UQE1 Q9UJP0
|
| Accessions |
AAB33239 AAB35274 AAC72301 AAF02415 AAF02416 AAU47275 AAU47276 AAU47278 AAU47279 AAU47281 AAU47282 AAU47284 AAU47285 AAU47287 AAU47288 AAU47290 AAU47291 AAU47293 AAU47294 AAU47296 AAU47297 AAU47299 AAU47300 AAU47302 AAU47303 AAU47305 AAU47306 AAU47308 AAU47309 AAU47311 AAU47312 AAU47314 AAU47315 AAU47317 AAU47318 AAU47320 AAU47321 AAU47323 AAU47324 AAU47326 AAU47327 AAW71991 ABA10403 ABA10404 ABA10406 ABA10407 ABA10409 ABA10410 ABA10412 ABA10413 ABA10415 ABA10416 ABA10418 ABA10419 ABA10421 ABA10422 ABA10424 ABA10425 ABA10427 ABA10428 ABA10430 ABA10431 ABA10433 ABA10434 ABA10436 ABA10437 ABA10439 ABA10440 ABA10442 ABA10443 ABA10445 ABA10446 ADD31869 ADD31870 AET81017 AET81018 AET81019 AET81020 AET81021 AET81022 AET81023 AET81024 AET81025 AET81026 AET81027 AET81028 AET81029 AET81030 AET81031 AET81032 AET81033 AET81034 AET81035 AET81036 AET81037 AET81038 AHL21240 AHL21241 AHL48496 AHL48497 AHL48498 AHL48499 AHL48500 AHL48501 AHL48502 AHL48503 AHN10451 AHN10452 AHN10453 AHN10454 AHN10455 AHN10456 CAA59770 CAA75133 CAP12644 CDH92902 CDJ79780 CDM21871 CEL12051 Q16570 AF030521 AAD20435 AK291593 BAF84282 AK309521 AY167991 AAO11657 BC017817 AAH17817 BC095496 AAH95496 BM671230 BX537430 CAD97672 CA435450 CD701182 DQ891966 ABM82892 DQ895155 ABM86081 EL735542 HE572751 CCC42287 JX081310 AFN67103 U01839 AAC50055 NM_001122951 NP_001116423 NM_002036 NP_002027
|
| Function |
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent prese
|
| Subcellular Location |
Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
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| Tissue Specificity |
Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.
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| Top Pathways |
Malaria
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