| Gene Symbol | Ehd2 |
|---|---|
| Entrez Gene | 259300 |
| Alt Symbol | BC027084, C130052H20Rik |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | EH-domain containing 2 |
| Other Description | EH domain-containing protein 2 |
| Swissprots | Q8BL28 Q8BH64 |
| Accessions | EDL42114 EDL42115 Q8BH64 AK029240 AK029557 AK031203 BAC27298 AK046566 BAC32789 AK048356 BAC33310 AK050243 BAC34142 AK084455 BAC39188 AK085016 BAC39339 AY531389 AAS48536 BC020014 AAH20014 BC027084 AAH27084 BC031731 BC113161 AAI13162 XM_011250582 XP_011248884 NM_153068 NP_694708 |
| Function | Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Binds ATP; does not bind GTP. {ECO:0000269|PubMed:14676205, ECO:0000269|PubMed:18502764, ECO:0000269|PubMed:21177873}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes. |
| Tissue Specificity | Detected in lung and adipocytes. Detected at lower levels in heart and skeletal muscle. {ECO:0000269|PubMed:14676205}. |
| Top Pathways | Endocytosis |