Gene Symbol | PIGN |
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Entrez Gene | 23556 |
Alt Symbol | MCAHS, MCAHS1, MCD4, MDC4, PIG-N |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class N |
Other Description | GPI ethanolamine phosphate transferase 1|MCD4 homolog|phosphatidylinositol-glycan biosynthesis class N protein |
Swissprots | Q7L8F8 O95427 Q9NT05 Q8TC01 |
Accessions | EAW63116 EAW63117 EAW63118 EAW63119 O95427 AF109219 AAD11432 AK000730 AK315134 BAG37585 AL137607 CAB70839 BC028363 AAH28363 BF112133 BM683126 BM830623 BQ023276 BU739970 DB093302 DB239067 JF432309 ADZ15526 XM_011525889 XP_011524191 XM_011525890 XP_011524192 XM_011525891 XP_011524193 XM_011525892 XP_011524194 XM_011525893 XP_011524195 XM_011525894 XP_011524196 XM_011525895 XP_011524197 XM_011525896 XP_011524198 XM_011525897 XP_011524199 XM_011525898 XP_011524200 NM_012327 NP_036459 NM_176787 NP_789744 |
Function | Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation. {ECO:0000250, ECO:0000269|PubMed:23446422}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-N CRISPR/Cas9 KO Plasmid (h) - sc-411766 from Santa Cruz Biotechnology
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PIG-N HDR Plasmid (h) - sc-411766-HDR from Santa Cruz Biotechnology
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PIG-N Double Nickase Plasmid (h) - sc-411766-NIC from Santa Cruz Biotechnology
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PIG-N Double Nickase Plasmid (h2) - sc-411766-NIC-2 from Santa Cruz Biotechnology
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PIG-N CRISPR Activation Plasmid (h) - sc-411766-ACT from Santa Cruz Biotechnology
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PIG-N CRISPR Activation Plasmid (h2) - sc-411766-ACT-2 from Santa Cruz Biotechnology
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PIG-N Lentiviral Activation Particles (h) - sc-411766-LAC from Santa Cruz Biotechnology
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PIG-N Lentiviral Activation Particles (h2) - sc-411766-LAC-2 from Santa Cruz Biotechnology
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PIG-N siRNA (h) - sc-76136 from Santa Cruz Biotechnology
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PIG-N shRNA Plasmid (h) - sc-76136-SH from Santa Cruz Biotechnology
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PIG-N shRNA (h) Lentiviral Particles - sc-76136-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16791 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10050 from Sigma-Aldrich
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PIGN siRNA (Human) - CRH8358 from Cohesion Biosciences
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shRNA set against Human PIGN (NM_176787.4) - SHH375456 from Creative biogene
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shRNA set against Human PIGN(NM_012327.5) - SHR114088 from Creative biogene
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Human PIGN siRNA - orb268860 from Biorbyt
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PIGN shRNA Plasmid (Human) - CHH8358 from Cohesion Biosciences
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PIGN miRNA 3'UTR clone - MiUTR1H-07895 from Creative biogene
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PIGN miRNA 3'UTR clone - MiUTR3H-08211 from Creative biogene
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