Gene Symbol | SC5D |
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Entrez Gene | 6309 |
Alt Symbol | ERG3, S5DES, SC5DL |
Species | Human |
Gene Type | protein-coding |
Description | sterol-C5-desaturase |
Other Description | 3beta-hydroxysteroid-delta5-desaturase|C-5 sterol desaturase|delta(7)-sterol 5-desaturase|fungal ERG3, delta-5-desaturase-like|lathosterol 5-desaturase|lathosterol dehydrogenase|lathosterol oxidase|sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like |
Swissprots | O75845 Q6GTM5 O00119 Q9UK15 |
Accessions | BAB68218 EAW67519 EAW67520 EAW67521 EAW67522 O75845 AF069469 AF187981 AAF00544 AK027246 AK096847 AK222686 BAD96406 AK223141 BAD96861 AK312634 BAG35518 BC012333 AAH12333 BC050427 AAH50427 BI559520 HQ447381 ADQ31867 R60770 NM_001024956 NP_001020127 NM_006918 NP_008849 |
Function | Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Top Pathways | Steroid biosynthesis |
Sc5d CRISPR/Cas9 KO Plasmid (h) - sc-418140 from Santa Cruz Biotechnology
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Sc5d HDR Plasmid (h) - sc-418140-HDR from Santa Cruz Biotechnology
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Sc5d Double Nickase Plasmid (h) - sc-418140-NIC from Santa Cruz Biotechnology
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Sc5d Double Nickase Plasmid (h2) - sc-418140-NIC-2 from Santa Cruz Biotechnology
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Sc5d CRISPR Activation Plasmid (h) - sc-418140-ACT from Santa Cruz Biotechnology
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Sc5d CRISPR Activation Plasmid (h2) - sc-418140-ACT-2 from Santa Cruz Biotechnology
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Sc5d Lentiviral Activation Particles (h) - sc-418140-LAC from Santa Cruz Biotechnology
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Sc5d Lentiviral Activation Particles (h2) - sc-418140-LAC-2 from Santa Cruz Biotechnology
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Sc5d siRNA (h) - sc-62980 from Santa Cruz Biotechnology
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Sc5d shRNA Plasmid (h) - sc-62980-SH from Santa Cruz Biotechnology
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Sc5d shRNA (h) Lentiviral Particles - sc-62980-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18876 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18876 from Sigma-Aldrich
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SC5D siRNA (Human) - CRH4251 from Cohesion Biosciences
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SC5D - MBS8225285 from MyBioSource
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shRNA set against Human Sc5d (NM_006918.4) - SHH402196 from Creative biogene
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shRNA set against Human SC5DL(NM_001024956.2) - SHR206256 from Creative biogene
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Human SC5D siRNA - orb264753 from Biorbyt
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SC5D shRNA Plasmid (Human) - CHH4251 from Cohesion Biosciences
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SC5DL miRNA 3'UTR clone - MiUTR1H-09148 from Creative biogene
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