| Gene Symbol |
DGAT1
|
| Entrez Gene |
282609
|
| Alt Symbol |
ARAT
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
diacylglycerol O-acyltransferase 1
|
| Other Description |
acyl-CoA retinol O-fatty-acyltransferase|diacylglycerol O-acyltransferase homolog 1|diglyceride acyltransferase|retinol O-fatty-acyltransferase
|
| Swissprots |
Q148M3 Q8MK44 Q8SQB0
|
| Accessions |
AAL49962 CAC86391 CAK22284 CAK22285 CAK22286 CAK22287 DAA22842 Q8MK44 BC118146 AAI18147 NM_174693 NP_777118
|
| Function |
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Top Pathways |
Fat digestion and absorption, Glycerolipid metabolism, Retinol metabolism
|