| Gene Symbol | DPF3 |
|---|---|
| Entrez Gene | 8110 |
| Alt Symbol | BAF45C, CERD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | D4, zinc and double PHD fingers, family 3 |
| Other Description | BRG1-associated factor 45C|zinc finger protein DPF3|zinc finger protein cer-d4 |
| Swissprots | B7Z276 Q6ZT41 A8MSI3 Q32UJ0 Q92784 Q6P9E6 F5H575 Q9H7Y5 |
| Accessions | AAC50686 EAW81076 EAW81077 EAW81078 EAW81079 EAW81080 Q92784 AK024141 BAB14838 AK123045 AK124615 AK124946 AK126074 AK126933 BAC86753 AK294425 BAH11762 AY803021 AAX20019 BC021812 BC026305 BC060801 AAH60801 BG218220 DA010060 DA407279 DB140241 DB172058 EU446740 ABZ92269 XM_011537191 XP_011535493 XM_011537192 XP_011535494 XM_011537193 XP_011535495 XM_011537194 XP_011535496 NM_001280542 NP_001267471 NM_001280543 NP_001267472 NM_001280544 NP_001267473 NM_012074 NP_036206 |
| Function | Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex invol |
| Subcellular Location | Nucleus {ECO:0000305}. |