| Gene Symbol |
Ext1
|
| Entrez Gene |
100689334
|
| Alt Symbol |
-
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
exostosin glycosyltransferase 1
|
| Other Description |
Heparan sulfate copolymerase|Multiple exostoses protein 1 homolog|exostoses (multiple) 1|exostosin 1|exostosin-1
|
| Swissprots |
Q9JK82
|
| Accessions |
Q9JK82 AF252858 AAF71276 JI868603 JP037686 NM_001246767 NP_001233696
|
| Function |
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus. {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|