SPHK1

Gene Symbol SPHK1
Entrez Gene 8877
Alt Symbol SPHK
Species Human
Gene Type protein-coding
Description sphingosine kinase 1
Other Description SK 1|SPK 1
Swissprots Q9NYA1 Q9NY70 Q9HD92 Q96GK1 Q8N632 Q9NYL3
Accessions AAP35060 CAE90363 CAE90969 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394 Q9NYA1 AF200328 AAG01980 AF238083 AAF73423 AF266756 AAF73470 AJ245504 CAB92131 AK022402 BAB14028 AK023393 BAB14558 AK095578 AK122781 BAG53725 AK225250 AK225258 AK292294 BAF84983 AK292614 BAF85303 BC004112 AAH04112 BC008040 AAH08040 BC009419 AAH09419 BC014439 AAH14439 BC030553 AAH30553 BP304783 DC384776 XM_005257766 XP_005257823 XM_011525439 XP_011523741 NM_001142601 NP_001136073 NM_001142602 NP_001136074 NM_021972 NP_068807 NM_182965 NP_892010
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.
Tissue Specificity Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269|PubMed:10802064}.
Top Pathways VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway

SphK1 CRISPR/Cas9 KO Plasmid (h) - sc-401274 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 HDR Plasmid (h) - sc-401274-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 Double Nickase Plasmid (h) - sc-401274-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 Double Nickase Plasmid (h2) - sc-401274-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 CRISPR Activation Plasmid (h) - sc-401274-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 CRISPR Activation Plasmid (h2) - sc-401274-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 Lentiviral Activation Particles (h) - sc-401274-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 Lentiviral Activation Particles (h2) - sc-401274-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SphK1 siRNA (h) - sc-44114 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SphK1 shRNA Plasmid (h) - sc-44114-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SphK1 shRNA (h) Lentiviral Particles - sc-44114-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SphK1 siRNA (h2) - sc-156038 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SphK1 shRNA Plasmid (h2) - sc-156038-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SphK1 shRNA (h2) Lentiviral Particles - sc-156038-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Sphingosine Kinase 1/SPHK1 RNAi - H00008877-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Sphingosine Kinase 1/SPHK1 RNAi - H00008877-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU064921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2108 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2109 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK2110 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1568 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1568 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02763 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02763

SPHK1 siRNA (Human) - CRH5864 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPHK1 - MBS8200514 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
Search more