| Gene Symbol | GSTT1 |
|---|---|
| Entrez Gene | 2952 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutathione S-transferase theta 1 |
| Other Description | GST class-theta-1|glutathione S-transferase theta-1|glutathione transferase T1-1 |
| Swissprots | Q6IC69 Q96IY3 Q969K8 P30711 O00226 Q5TZY2 |
| Accessions | AAG02374 BAB39498 EAW59629 EAW59630 EAW59631 EAW59632 EAW59633 EAW59634 EAW59635 P30711 AA298437 AF435971 AAL31549 AJ867757 CAI30331 AJ867758 CAI30332 AJ874719 CAI44003 AK311138 AL359937 BC007065 AAH07065 BC050410 BC064833 BF343733 BG536639 BM765626 BT019951 AAV38754 BX401239 CA306446 CA313466 CA487832 CD701199 CR456499 CAG30385 CU013096 CAK54527 CU013384 CAK54826 DA900601 DQ893480 ABM84406 DQ896757 ABM87756 X79389 CAA55935 XM_005261587 XP_005261644 NM_000853 NP_000844 NM_001293807 NP_001280736 NM_001293808 NP_001280737 NM_001293809 NP_001280738 NM_001293810 NP_001280739 NM_001293811 NP_001280740 NM_001293812 NP_001280741 NM_001293813 NP_001280742 NM_001293814 NP_001280743 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. {ECO:0000269|PubMed:16298388, ECO:0000269|PubMed:20097269}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles. {ECO:0000269|PubMed:8761485}. |
| Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |