| Gene Symbol |
DIO2
|
| Entrez Gene |
373903
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
deiodinase, iodothyronine, type II
|
| Other Description |
5DII|DIOII|type 2 DI|type II iodothyronine deiodinase|type-II 5'-deiodinase
|
| Swissprots |
Q9IAX2
|
| Accessions |
Q9IAX2 AF125575 AAD33251 AF401753 AAM93060 NM_204114 NP_989445
|
| Function |
Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. {ECO:0000250|UniProtKB:Q92813, ECO:0000269|PubMed:10318780}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in liver and in various parts of the brain including telencephalon, hippocampus, cerebellum, and brain stem, and weakly expressed in thyroid, lung, and small intestine. Not detected in skeletal muscle, heart atria or ventricle, gizzard or kidney. {ECO:0000269|PubMed:10318780}.
|