Gene Symbol |
AIDA
|
Entrez Gene |
64853
|
Alt Symbol |
C1orf80
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
axin interactor, dorsalization associated
|
Other Description |
axin interaction partner and dorsalization antagonist|axin interactor, dorsalization-associated protein
|
Swissprots |
Q5JRA4 Q658P1 A8K1F0 Q9H9E8 Q49A81 Q96BJ3
|
Accessions |
EAX06366 Q96BJ3 AF131838 AK022868 BAB14281 AK289865 BAF82554 AK301870 BAH13571 AL833718 CAH56257 BC015535 AAH15535 BC043142 AAH43142 BC067805 AAH67805 BC171848 AAI71848 BG705886 DA483113 XR_921909 NM_022831 NP_073742
|
Function |
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). {ECO:0000250}.
|
Tissue Specificity |
Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. {ECO:0000269|PubMed:17681137}.
|