| Gene Symbol |
ARC
|
| Entrez Gene |
395075
|
| Alt Symbol |
ARG3.1
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
activity-regulated cytoskeleton-associated protein
|
| Other Description |
ARC/ARG3.1|activity-regulated gene 3.1 protein homolog
|
| Swissprots |
Q8AWC3
|
| Accessions |
Q8AWC3 AJ272062 CAC81239 NM_204432 NP_989763
|
| Function |
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity in an NMDA receptor-dependent manner. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q63053}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines (By similarity). {ECO:0000250|UniProtKB:Q63053}.
|
| Tissue Specificity |
Expressed at various levels throughout the brain. {ECO:0000269|PubMed:15908132}.
|