| Gene Symbol | Fos |
|---|---|
| Entrez Gene | 100689418 |
| Alt Symbol | - |
| Species | Hamster |
| Gene Type | protein-coding |
| Description | FBJ murine osteosarcoma viral oncogene homolog |
| Other Description | Cellular oncogene fos|FBJ osteosarcoma oncogene|c-fos protooncogene protein|proto-oncogene c-Fos |
| Swissprots | Q9Z2Q8 |
| Accessions | Q9Z2Q8 AF033012 AAC83461 NM_001246683 NP_001233612 |
| Function | Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta- mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30 (By similarity). {ECO:0000250}. |
| Top Pathways | Choline metabolism in cancer, Oxytocin signaling pathway, cAMP signaling pathway, Toll-like receptor signaling pathway, Pertussis |