CRCP
| Gene Symbol | CRCP |
|---|---|
| Entrez Gene | 27297 |
| Alt Symbol | CGRP-RCP, CGRPRCP, RCP, RCP9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CGRP receptor component |
| Other Description | CGRP-receptor component protein|DNA-directed RNA polymerase III subunit RPC9|RNA polymerase III subunit C9|calcitonin gene-related peptide-receptor component protein |
| Swissprots | Q3KRA3 O75575 A8MW23 A8MUZ4 Q5HYF1 B4E198 B2R4H4 Q8IXL4 |
| Accessions | EAX07941 EAX07942 EAX07943 O75575 AF073792 AAC25992 AK023295 AK290553 BAF83242 AK303737 BAG64710 AK311829 BAG34771 BC040107 AAH40107 BC052570 BC105808 AAI05809 BI600330 BX647867 CAI46069 DA821665 DA955978 DB472426 U51134 AAD05036 NM_001040647 NP_001035737 NM_001040648 NP_001035738 NM_001142414 NP_001135886 NM_014478 NP_055293 NR_024548 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Most prevalent in testis. {ECO:0000269|PubMed:10067875}. |
CGRP-RCP CRISPR/Cas9 KO Plasmid (h) - sc-404583 from Santa Cruz Biotechnology
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CGRP-RCP HDR Plasmid (h) - sc-404583-HDR from Santa Cruz Biotechnology
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CGRP-RCP Double Nickase Plasmid (h) - sc-404583-NIC from Santa Cruz Biotechnology
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CGRP-RCP Double Nickase Plasmid (h2) - sc-404583-NIC-2 from Santa Cruz Biotechnology
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CGRP-RCP CRISPR Activation Plasmid (h) - sc-404583-ACT from Santa Cruz Biotechnology
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CGRP-RCP CRISPR Activation Plasmid (h2) - sc-404583-ACT-2 from Santa Cruz Biotechnology
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CGRP-RCP Lentiviral Activation Particles (h) - sc-404583-LAC from Santa Cruz Biotechnology
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CGRP-RCP Lentiviral Activation Particles (h2) - sc-404583-LAC-2 from Santa Cruz Biotechnology
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CGRP-RCP siRNA (h) - sc-45539 from Santa Cruz Biotechnology
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CGRP-RCP shRNA Plasmid (h) - sc-45539-SH from Santa Cruz Biotechnology
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CGRP-RCP shRNA (h) Lentiviral Particles - sc-45539-V from Santa Cruz Biotechnology
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CRCP RNAi - H00027297-R01 from Novus Biologicals
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MISSION® esiRNA - EHU113671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6549 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6549 from Sigma-Aldrich
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CRCP siRNA (Human) - CRH9064 from Cohesion Biosciences
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CRCP RNAi - H00027297-R02 from Novus Biologicals
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CRCP RNAi - H00027297-R03 from Novus Biologicals
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CRCP - MBS8240032 from MyBioSource
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shRNA set against Human CRCP (NM_014478.4) - SHH269249 from Creative biogene
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shRNA set against Human RCP9(NM_014478.4) - SHG197767 from Creative biogene
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shRNA set against Human RCP9(NM_001040647.1) - SHG197785 from Creative biogene
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shRNA set against Human RCP9(NM_001040648.1) - SHG197821 from Creative biogene
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Human CRCP siRNA - orb269566 from Biorbyt
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CRCP shRNA Plasmid (Human) - CHH9064 from Cohesion Biosciences
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