CTNNA1

Gene Symbol	CTNNA1
Entrez Gene	1495
Alt Symbol	CAP102
Species	Human
Gene Type	protein-coding
Description	catenin (cadherin-associated protein), alpha 1, 102kDa
Other Description	alpha E-catenin|alpha-E-catenin|alpha-catenin|alphaE-catenin|cadherin-associated protein,102kDa|catenin alpha-1|renal carcinoma antigen NY-REN-13
Swissprots	Q8N1C0 Q12795 P35221
Accessions	AAC99459 AAW56940 EAW62122 EAW62123 EAW62124 P35221 AI078507 AK055751 AK094151 BAG52830 AK296708 BAG59301 AK300439 BAG62162 AK304267 BAG65130 AU141929 BC000385 AAH00385 BC031262 AAH31262 BU624488 D13866 BAA02979 D14705 BAA03530 DA349847 DC369291 DQ891250 ABM82176 DQ894435 ABM85361 HQ589335 AEF32483 L22080 AAA35502 L23805 AAA86430 U03100 AAA18949 XM_005271899 XP_005271956 XM_006714536 XP_006714599 XM_011543172 XP_011541474 NM_001290307 NP_001277236 NM_001290309 NP_001277238 NM_001290310 NP_001277239 NM_001290312 NP_001277241 NM_001903 NP_001894
Function	Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Subcellular Location	Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.
Tissue Specificity	Expressed ubiquitously in normal tissues.
Top Pathways	Adherens junction, Tight junction, Leukocyte transendothelial migration, Endometrial cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

alpha 1 Catenin peptide - ab48073 from Abcam Category Peptide Prices $290.00 Sizes 100 µg

Human alpha 1 Catenin full length protein - ab158226 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human alpha 1 Catenin full length protein - ab51443 from Abcam Category Protein Prices $388.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human alpha 1 Catenin protein fragment - ab158227 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CTNNA1 Antibody Blocking Peptide - LS-E8308 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CTNNA1 Antibody Blocking Peptide - LS-E26092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Catenin alpha 1 Protein - H00001495-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Catenin alpha 1 Protein - H00001495-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CTNA1-Antibody-C-term-Blocking-Peptide - BP6582b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CTNA1-Antibody-N-term-Blocking-Peptide - BP6582a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

alpha 1 Catenin blocking peptide - GTX89347-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Alpha E-catenin peptide - orb217155 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Cat

alpha 1 Catenin Peptide - AC21-0920-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Catenin alpha-1 / CTNNA1 - H00001495-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Catenin alpha-1 / CTNNA1 - H00001495-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Catenin alpha-1 / CTNNA1 - H00001495-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Catenin alpha-1 / CTNNA1 - H00001495-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Catenin alpha 1 Peptide - 45-364P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CTNNA1 fusion protein - Ag23603 from Proteintech Group Category Protein Source E. coli -derived, PET30a Species Human

CTNNA1 fusion protein - Ag3565 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CTNNA1,GST-tagged - CTNNA1-1440H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human CTNNA1, GST-tagged - CTNNA1-11669H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CTNNA1 - CTNNA1-168H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Catenin Alpha 1 (CTNNa1) - RPC201Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Catenin alpha protein-GST fusion - 009-001-R57 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

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