ABCG2

Gene Symbol	ABCG2
Entrez Gene	9429
Alt Symbol	ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Other Description	ABC transporter|ATP-binding cassette sub-family G member 2|ATP-binding cassette transporter G2|breast cancer resistance protein|mitoxantrone resistance-associated protein|multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2|placenta specific MDR protein|placenta-specific ATP-binding cassette transporter|urate exporter
Swissprots	Q9BY73 Q9NUS0 Q8IX16 O95374 A8K1T5 Q569L4 Q53ZQ1 Q4W5I3 A0A1W3 Q96LD6 Q96TA8 Q9UNQ0 Q5YLG4 Q86V64
Accessions	AAY40902 ABI97388 CAF32512 EAX06012 EAX06013 Q9UNQ0 AB051855 BAB46933 AB056867 BAB39212 AF093771 AF093772 AF098951 AAC97367 AF103796 AAD09188 AF151530 AF463519 AAO14617 AK002040 BAA92050 AK290000 BAF82689 AY017168 AAG52982 AY288307 AAP31310 AY289766 AAP44087 AY333755 AAQ92941 AY333756 AAQ92942 BC011032 BC021281 AAH21281 BC092408 AAH92408 BI598784 DQ459561 DQ459562 DQ459563 DQ459564 DQ459565 DQ459566 DQ459567 DQ459568 DQ459570 DQ459571 DQ459572 DQ459573 DQ459574 DQ459575 DQ459576 DQ459577 DQ459578 DQ459579 DQ459580 DQ459581 DQ459582 DQ459583 DQ459584 DQ459585 DQ459586 DQ459587 DQ459588 DQ459589 DQ459590 DQ459591 DQ459592 DQ459593 DQ459594 DQ459595 DQ459596 DQ459597 DQ459598 DQ459599 DQ459600 DQ459601 DQ459602 DQ459603 DQ459604 DQ459605 DQ459606 DQ459607 DQ459608 DQ459609 DQ459610 DQ459611 DQ459612 DQ459613 DQ459614 DQ892308 ABM83234 DQ895507 ABM86433 HQ386990 ADO95109 HQ386991 ADO95110 HQ386992 ADO95111 HQ386993 ADO95112 HQ386994 ADO95113 HQ386995 ADO95114 HQ386996 ADO95115 HQ386997 ADO95116 HQ386998 ADO95117 HQ386999 ADO95118 HQ387000 ADO95119 HQ387001 ADO95120 HQ387002 ADO95121 HQ387003 ADO95122 HQ387004 ADO95123 HQ387005 ADO95124 HQ387006 ADO95125 HQ387007 ADO95126 U66681 XM_005263354 XP_005263411 XM_005263355 XP_005263412 XM_005263356 XP_005263413 XM_011532420 XP_011530722 NM_001257386 NP_001244315 NM_004827 NP_004818
Function	High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Tissue Specificity	Highly expressed in placenta. Low expression in small intestine, liver and colon. {ECO:0000269|PubMed:9850061, ECO:0000269|PubMed:9861027}.
Top Pathways	ABC transporters, Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BCRP/ABCG2 full length protein - ab152985 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human BCRP/ABCG2 peptide - ab100820 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human BCRP/ABCG2 protein fragment - ab152986 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human BCRP/ABCG2 protein fragment - ab152987 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Recombinant Human ABCG2/CD338 Protein - H00009429-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ABCG2/CD338 Protein - H00009429-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ABCG2/CD338 Protein - H00009429-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ABCG2/CD338 Recombinant Protein - H00009429-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

ABCG2/CD338 Peptide - P0484 from Novus Biologicals Category Peptide Species Human

ABCG2/CD338 Peptide - P0483 from Novus Biologicals Category Peptide Species Human

ABCG2-BCRP-Antibody-Center-Blocking-peptide - BP1490c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ABCG2-BCRP-Antibody-C-term-Blocking-peptide - BP1490b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ABCG2 Blocking Peptide - 33R-8455 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ABCG2 Blocking Peptide - abx161245 from Abbexa Category Peptide Species Human

ABCG2 Blocking Peptide - abx063584 from Abbexa Category Peptide Species Human, Mouse, Rat

CD338 / ABCG2 / BCRP1 - H00009429-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD338 / ABCG2 / BCRP1 - H00009429-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CD338 / ABCG2 / BCRP1 - H00009429-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD338 / ABCG2 / BCRP1 - H00009429-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD338 / ABCG2 / BCRP1 - H00009429-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CD338 / ABCG2 / BCRP1 - H00009429-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD338 / ABCG2 / BCRP1 - H00009429-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BCRP,ABCG2 fusion protein - ag4869 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

BCRP,ABCG2 fusion protein - ag0223 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ABCG2 - ABCG2-659H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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