CLIC5

Gene Symbol	CLIC5
Entrez Gene	53405
Alt Symbol	DFNB102, DFNB103, MST130, MSTP130
Species	Human
Gene Type	protein-coding
Description	chloride intracellular channel 5
Other Description	chloride intracellular channel protein 5
Swissprots	Q9BWZ0 Q5T4Z0 Q9NZA1 Q96JT5 Q8NBY3 B3KUF1
Accessions	CAF86413 CAF86432 EAX04285 EAX04286 EAX04287 Q9NZA1 AF086005 AF176920 AAQ13664 AF216941 AAF66928 AJ420547 AK025350 AK075144 BAC11432 AK075163 BAC11444 AK097048 BAG53413 AK222544 BAD96264 AK223130 BAD96850 AK314416 BAG37037 AL049313 AY032602 AAK52083 BC020923 AAH20923 BC035968 AAH35968 BC039380 AAH39380 BI559571 BP369816 BQ184144 DA843541 DQ679794 ABG46342 DQ892643 ABM83569 DQ895881 ABM86807 XM_011514692 XP_011512994 XM_011514693 XP_011512995 XM_011514694 XP_011512996 XM_011514695 XP_011512997 XR_926257 XR_926258 XR_926259 NM_001114086 NP_001107558 NM_001256023 NP_001242952 NM_016929 NP_058625 NR_045672 NR_045673 NR_045674
Function	Required for normal hearing (PubMed:24781754). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (PubMed:15184393, PubMed:18028448, PubMed:20335315). {ECO:0000250|UniProtKB:Q8BXK9, ECO:0000269|PubMed:15184393, ECO:0000269|PubMed:18028448, ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}.
Subcellular Location	Isoform 1: Cytoplasm, cell cortex {ECO:0000269|PubMed:15184393}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15184393}. Membrane {ECO:0000269|PubMed:15184393}; Single-pass membrane protein {ECO:0000269|PubMed:15184393}. Note=Associates with the cortical actin cytoskeleton. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed in both fetal and adult human tissues (PubMed:24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLIC5 protein fragment - ab162692 from Abcam Category Protein Source Wheat germ Species Human

Human CLIC5 protein fragment - ab151380 from Abcam Category Protein Source E. coli Species Human

CLIC5 Antibody Blocking Peptide - LS-E9075 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLIC5 Antibody Blocking Peptide - LS-E12543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CLIC5 Protein - H00053405-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CLIC5-Antibody-Blocking-Peptide - BP7583a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLIC5 Blocking Peptide - 33R-10228 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CLIC5 Blocking Peptide - 33R-3815 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CLIC5 - H00053405-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CLIC5 - H00053405-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Chloride Intracellular Channel Protein 5CLIC5 - 19-C212 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

CLIC5 fusion protein - Ag2322 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CLIC5 Protein - BP001748-C212 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CLIC5, His-tagged - CLIC5-7653H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CLIC5, GST-tagged - CLIC5-11328H from Creative Biomart Category Protein Source E.coli Species Human

CLIC5 (transcript variant 2) - TP305906 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CLIC5 (transcript variant 1) - TP720188 from Acris Antibodies Category Protein Prices $399.00 Sizes 10 µg Source E. coli Species Human

CLIC5 Peptide, Human - M34GP03285H from Creative Peptides Category Peptide Source Synthetic. Species Human

CLIC5 Recombinant Protein - 91-192 from ProSci Category Protein Prices $525.00 Sizes 50 µg Source E. coli Species Human

Chloride intracellular channel protein 5 (CLIC5), Recombinant Protein - MBS7011630 from MyBioSource Category Protein Prices $1,215.00, $2,200.00, $3,410.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

CLIC5, Recombinant Protein - MBS8248802 from MyBioSource Category Protein Prices $255.00, $635.00, $2,370.00 Sizes 10 µg, 50 µg, 500 µg Source E Coli Species Human

Recombinant Human Chloride Intracellular Channel Protein 5,CLIC5 (N-6His) - AP74944 from Signalway Antibody Category Protein Prices $349.00, $749.00, $2,289.00, $3,209.00 Sizes 10 µg, 50 µg, 500 µg, 1 mg Source E.coli Species Human

Human CLIC5 protein - orb391492 from Biorbyt Category Protein Species Human

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