| Gene Symbol |
CAPZB
|
| Entrez Gene |
396418
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
capping protein (actin filament) muscle Z-line, beta
|
| Other Description |
F-actin-capping protein subunit beta|actin-capping protein Z (cap-Z) beta subunit|beta-actinin subunit II|capZ 36/32|capZ B1 and B2
|
| Swissprots |
P14315
|
| Accessions |
P14315 J04959 AAA49144 U07826 AAA52222 NM_001173529 NP_001167000 NM_205437 NP_990768
|
| Function |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the regulation of cell morphology and cytoskeletal organization.
|
| Subcellular Location |
Isoform 1: Cytoplasm, myofibril, sarcomere, Z line. Note=In cardiac muscle, isoform 1 is located at Z-disks of sarcomeres.
|
| Tissue Specificity |
Isoform 1 is detected in pectoral muscle, cardiac muscle and gizzard. Isoform 2 is detected in brain and liver (at protein level). Isoform 2 is the predominant isoform of nonmuscle tissues and isoform 1 is the predominant isoform of muscle tissues. {ECO:0000269|PubMed:7929588}.
|
