CASP8
| Gene Symbol | CASP8 |
|---|---|
| Entrez Gene | 841 |
| Alt Symbol | ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | caspase 8, apoptosis-related cysteine peptidase |
| Other Description | FADD-homologous ICE/CED-3-like protease|FADD-like ICE|ICE-like apoptotic protease 5|MACH-alpha-1/2/3 protein|MACH-beta-1/2/3/4 protein|MORT1-associated ced-3 homolog|apoptotic cysteine protease|apoptotic protease Mch-5|caspase 8, apoptosis-related cysteine protease|caspase-8 |
| Swissprots | Q14791 Q8TDI4 O14676 Q14790 Q9C0K4 Q8TDI1 Q14794 Q9UQ81 Q14796 Q8TDI2 Q14795 Q15780 Q14793 Q96T22 Q14792 Q8TDI3 Q15806 Q53TT5 Q8TDI5 |
| Accessions | AAD24962 AAG10682 AAY24225 ABC67468 BAB32555 CAC39526 CAZ39541 CBX53871 CBX53872 CBX53873 CBX53874 EAW70253 EAW70254 EAW70258 EAW70262 Q14790 AA312258 AB451282 BAG70096 AB451414 BAG70228 AF009620 AAB70913 AF380342 AAK57437 AF422926 AAL87629 AF422927 AAL87630 AF422928 AAL87631 AF422929 AAL87632 AI351872 AK310630 AL600571 AL601594 AL702116 AY429525 BC010390 BC017031 BC028223 BC068050 AAH68050 BG236020 BG498355 BX395849 CB990598 DA420056 DB157537 EU168332 ABX09989 EU670044 ACF93415 JN657192 AFI38959 U58143 AAC50602 U60520 AAC50645 X98172 CAA66853 X98173 CAA66854 X98174 CAA66855 X98175 CAA66856 X98176 CAA66857 X98177 CAA66858 X98178 CAA66859 XM_005246885 XP_005246942 XM_005246886 XP_005246943 XM_005246887 XP_005246944 XM_005246888 XP_005246945 XM_005246889 XP_005246946 XM_005246890 XP_005246947 XM_005246891 XP_005246948 XM_005246892 XP_005246949 XM_005246893 XP_005246950 XM_005246894 XP_005246951 XM_005246895 XP_005246952 XM_006712789 XP_006712852 XM_006712790 XP_006712853 XM_006712791 XP_006712854 XM_006712793 XP_006712856 XM_011511968 XP_011510270 XM_011511969 XP_011510271 XM_011511970 XP_011510272 XR_923035 NM_001080124 NP_001073593 NM_001080125 NP_001073594 NM_001228 NP_001219 NM_033355 NP_203519 NM_033356 NP_203520 NM_033358 NP_203522 NR_111983 NM_033357 |
| Function | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:9006941}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle. |
| Top Pathways | Chagas disease (American trypanosomiasis), Viral carcinogenesis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Legionellosis |
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