Gene Symbol | CTSA |
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Entrez Gene | 5476 |
Alt Symbol | GLB2, GSL, NGBE, PPCA, PPGB |
Species | Human |
Gene Type | protein-coding |
Description | cathepsin A |
Other Description | beta-galactosidase 2|beta-galactosidase protective protein|carboxypeptidase C|carboxypeptidase L|carboxypeptidase Y-like kininase|carboxypeptidase-L|deamidase|lysosomal carboxypeptidase A|lysosomal protective protein|protective protein cathepsin A|urinary kininase |
Swissprots | Q561W6 Q5JZH1 Q9BW68 B2R798 P10619 Q9BR08 Q96KJ2 |
Accessions | AAM09560 CCQ43096 EAW75788 EAW75789 P10619 AB209705 BAD92942 AF086236 AK055177 AK097786 AK172808 AK304536 BAG65336 AK307701 AK312898 BAG35745 BC000597 AAH00597 BC093009 AAH93009 DA029446 DQ891935 ABM82861 DQ895122 ABM86048 M22960 AAA36476 NM_000308 NP_000299 NM_001127695 NP_001121167 NM_001167594 NP_001161066 |
Function | Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. {ECO:0000269|PubMed:1907282}. |
Subcellular Location | Lysosome. |
Top Pathways | Lysosome, Renin-angiotensin system |
cathepsin A CRISPR/Cas9 KO Plasmid (h) - sc-402785 from Santa Cruz Biotechnology
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cathepsin A HDR Plasmid (h) - sc-402785-HDR from Santa Cruz Biotechnology
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cathepsin A Double Nickase Plasmid (h) - sc-402785-NIC from Santa Cruz Biotechnology
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cathepsin A Double Nickase Plasmid (h2) - sc-402785-NIC-2 from Santa Cruz Biotechnology
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cathepsin A CRISPR Activation Plasmid (h) - sc-402785-ACT from Santa Cruz Biotechnology
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cathepsin A CRISPR Activation Plasmid (h2) - sc-402785-ACT-2 from Santa Cruz Biotechnology
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cathepsin A Lentiviral Activation Particles (h) - sc-402785-LAC from Santa Cruz Biotechnology
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cathepsin A Lentiviral Activation Particles (h2) - sc-402785-LAC-2 from Santa Cruz Biotechnology
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cathepsin A siRNA (h) - sc-41469 from Santa Cruz Biotechnology
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cathepsin A shRNA Plasmid (h) - sc-41469-SH from Santa Cruz Biotechnology
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cathepsin A shRNA (h) Lentiviral Particles - sc-41469-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU062531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6749 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02902 from Sigma-Aldrich
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CTSA siRNA (Human) - CRH3674 from Cohesion Biosciences
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Cathepsin A/Lysosomal Carboxypeptidase A RNAi - H00005476-R01 from Novus Biologicals
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CTSA - MBS829182 from MyBioSource
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shRNA set against Human CTSA (NM_000308.2) - SHH271481 from Creative biogene
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shRNA set against Human CTSA(NM_000308.2) - SHG172441 from Creative biogene
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Human CTSA siRNA - orb264176 from Biorbyt
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CTSA shRNA Plasmid (Human) - CHH3674 from Cohesion Biosciences
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CTSA miRNA 3'UTR clone - MiUTR1H-02541 from Creative biogene
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CTSA miRNA 3'UTR clone - MiUTR3H-12745 from Creative biogene
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