| Gene Symbol |
ACVR2B
|
| Entrez Gene |
374213
|
| Alt Symbol |
ACTR-IIB
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
activin A receptor, type IIB
|
| Other Description |
activin receptor type IIB|activin receptor type-2B
|
| Swissprots |
Q90670
|
| Accessions |
Q90670 U31223 AAA87842 NM_204317 NP_989648
|
| Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. May modulate neuropeptide expression in dorsal root ganglia (DRG) neurons and ovarian follicle development. {ECO:0000269|PubMed:11291100, ECO:0000269|PubMed:16039645, ECO:0000269|PubMed:16461550, ECO:0000269|PubMed:7589799}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Not expressed in hen anterior pituitary during the ovulatory cycle but expressed in the ovarian follicle. {ECO:0000269|PubMed:16135664, ECO:0000269|PubMed:16461550}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
|