| Gene Symbol |
CDC42
|
| Entrez Gene |
403934
|
| Alt Symbol |
-
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle 42 (GTP binding protein, 25kDa)
|
| Other Description |
CDC42 GTP-binding protein|G25K GTP-binding protein|cell division control protein 42 homolog
|
| Swissprots |
P60952
|
| Accessions |
P60952 Z49944 CAA90215 NM_001003254 NP_001003254
|
| Function |
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
|
| Top Pathways |
Bacterial invasion of epithelial cells, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), Salmonella infection, Chemokine signaling pathway
|
