Gene Symbol | KCNIP4 |
---|---|
Entrez Gene | 80333 |
Alt Symbol | CALP, KCHIP4 |
Species | Human |
Gene Type | protein-coding |
Description | Kv channel interacting protein 4 |
Other Description | Kv channel-interacting protein 4|a-type potassium channel modulatory protein 4|calsenilin-like protein|potassium channel interacting protein 4|potassium channel-interacting protein 4 |
Swissprots | Q9BWT2 Q9H2A4 Q9H294 Q6PIL6 Q3YAB9 Q3YAC0 Q4W5G8 Q8NEU0 Q3YAC1 Q3YAC2 Q3YAB8 |
Accessions | AAL86767 AAY40911 AAY40952 CAD35225 CAD35226 EAW92797 EAW92798 Q6PIL6 AF302044 AAG36974 AF305072 AAG36977 AF367023 AAK53712 AF367024 AAK53713 AF453246 AAL86769 AK289661 BAF82350 AK289922 BAF82611 AK290998 BAF83687 AK294188 BAG57504 AK314058 AY029176 AAK31594 AY118170 AAM81578 BC032520 AAH32520 BI596848 BX648990 DQ148487 AAZ77804 DQ148488 AAZ77805 DQ148489 AAZ77806 DQ148490 AAZ77807 DQ148491 AAZ77808 DQ148492 AAZ77809 EU446535 ABZ92064 XM_005248190 XP_005248247 XM_011513882 XP_011512184 XM_011513883 XP_011512185 XM_011513884 XP_011512186 XM_011513885 XP_011512187 XM_011513886 XP_011512188 XM_011513887 XP_011512189 XM_011513888 XP_011512190 XM_011513889 XP_011512191 NM_001035003 NP_001030175 NM_001035004 NP_001030176 NM_025221 NP_079497 NM_147181 NP_671710 NM_147182 NP_671711 NM_147183 NP_671712 |
Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. {ECO:0000250|UniProtKB:Q6PHZ8, ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:18957440, ECO:0000269|PubMed:23576435}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:11847232}; Peripheral membrane protein {ECO:0000305|PubMed:11847232}. Cytoplasm {ECO:0000269|PubMed:11847232, ECO:0000269|PubMed:23576435}. |
Tissue Specificity | Predominantly expressed in brain. {ECO:0000269|PubMed:11847232}. |