| Gene Symbol |
Slc30a7
|
| Entrez Gene |
66500
|
| Alt Symbol |
1810059J10Rik, 2610034N15Rik, 4833428C12Rik, AI467242, ZnT-7, ZnT7, Zntl2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 30 (zinc transporter), member 7
|
| Other Description |
solute carrier family 30 member 7|zinc transporter 7|znt-like transporter 2
|
| Swissprots |
Q9JKN1 Q80Y27
|
| Accessions |
EDL12392 Q9JKN1 AF233322 AAF43423 AF529196 AAO17323 AI131675 AI451495 AI467242 AK010008 BAB26639 AK011675 AK053202 AK075802 BAC35970 AK076492 AV250971 AW125624 BC017136 AAH17136 BC050193 AAH50193 XM_011240194 XP_011238496 NM_023214 NP_075703
|
| Function |
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12446736}; Multi-pass membrane protein {ECO:0000269|PubMed:12446736}.
|
| Tissue Specificity |
Highly expressed in liver, spleen, duodenum and part of the jejunum of small intestine (at protein level). Moderately expressed in kidney, lung, and brain. Barely detectable in heart. {ECO:0000269|PubMed:12446736, ECO:0000269|PubMed:17954933}.
|