| Gene Symbol |
Lnpep
|
| Entrez Gene |
171105
|
| Alt Symbol |
IRAP, P-LAP, Vp165
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
leucyl/cystinyl aminopeptidase
|
| Other Description |
GP160|OTase|aminopeptidase Vp165|angiotensin IV receptor|cystinyl aminopeptidase|insulin-regulated membrane aminopeptidase IRAP|insulin-responsive aminopeptidase|leucyl-cystinyl aminopeptidase|oxytocinase|placental leucine aminopeptidase|vesicle protein of 165 kDa
|
| Swissprots |
Q11009 P97629
|
| Accessions |
EDL99798 EDL99799 EDL99800 P97629 AY079189 AAL86569 U32990 AAB38021 U76997 AAB19066 NM_133574 NP_598258 NM_001113403 NP_001106874
|
| Function |
Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. Endomembrane system; Single-pass type II membrane protein. Note=Localized mainly in intracellular vesicles together with GLUT4. Relocalizes to the plasma membrane in response to insulin. The dileucine internalization motif and/or the interaction with tankyrases may be involved in intracellular sequestration.
|
| Tissue Specificity |
Highly expressed in heart, brain, spleen, lung, kidney and white adipose tissue. Detected at lower levels in skeletal muscle and liver.
|
| Top Pathways |
Renin-angiotensin system
|