| Gene Symbol |
CHN2
|
| Entrez Gene |
1124
|
| Alt Symbol |
ARHGAP3, BCH, CHN2-3, RHOGAP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chimerin 2
|
| Other Description |
beta-chimaerin|beta-chimerin|beta3-chimaerin|chimerin (chimaerin) 2|chimerin, beta-2|chimerin, testis-specific|rho-GTPase-activating protein 3
|
| Swissprots |
F8QPL9 C9J7B0 Q75MM2 B3VCG1 B3VCF2 B3VCF1 Q2M203 B3VCF3 E9PGE0 A4D1A2 P52757 B3VCF7
|
| Accessions |
AAC06177 AAS02045 AAS07498 EAL24205 EAL24206 EAW93919 P52757 AA521339 AK026415 AK124021 AK126784 AK293959 BAH11636 AK294032 BAH11655 AK294216 BAH11701 AK294271 BAH11718 AK301235 BAH13437 AK313021 BAG35856 AK316030 BAH14401 BC112155 AAI12156 BQ446523 BU743119 DA096970 DA105459 DA190643 EU732750 ACF04987 EU732751 ACF04988 EU732752 ACF04989 EU732753 ACF04990 EU732754 ACF04991 EU732755 ACF04992 EU732756 ACF04993 EU732757 ACF04994 EU732758 ACF04995 EU732759 ACF04996 EU732760 ACF04997 EU732761 ACF04998 EU732762 ACF04999 EU732763 ACF05000 EU732764 ACF05001 EU732765 ACF05002 EU732766 ACF05003 GQ924106 ADK47390 U28926 AAA86528 XM_011515105 XP_011513407 XM_011515106 XP_011513408 XM_011515107 XP_011513409 XM_011515108 XP_011513410 XM_011515109 XP_011513411 XM_011515110 XP_011513412 XM_011515111 XP_011513413 XM_011515112 XP_011513414 NM_001039936 NP_001035025 NM_001293069 NP_001279998 NM_001293070 NP_001279999 NM_001293071 NP_001280000 NM_001293072 NP_001280001 NM_001293073 NP_001280002 NM_001293075 NP_001280004 NM_001293076 NP_001280005 NM_001293077 NP_001280006 NM_001293078 NP_001280007 NM_001293079 NP_001280008 NM_001293080 NP_001280009 NM_001293081 NP_001280010 NM_004067 NP_004058 NR_120524 NR_120525
|
| Function |
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
|
| Subcellular Location |
Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.
|
![Western Blot: Chimaerin 2 Overexpression Lysate (Adult Normal) [NBL1-09166] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Chimaerin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/9206_Chimaerin%25202%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09166-img0002.jpg)