| Gene Symbol |
Vdac3
|
| Entrez Gene |
83532
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
voltage-dependent anion channel 3
|
| Other Description |
VDAC-3|mitochondrial voltage dependent anion channel 3|outer mitochondrial membrane protein porin 3|rVDAC3|voltage-dependent anion-selective channel protein 3
|
| Swissprots |
Q9ESR2 Q9R1Z0 Q9WTU2 Q9JI31 Q6GSZ1
|
| Accessions |
EDM09005 EDM09006 Q9R1Z0 AB039664 BAB13475 AF048829 AAD22722 AF048830 AAD22723 AF268469 AAF80117 BC061780 AAH61780 FQ215155 FQ215672 FQ215800 FQ216595 FQ216638 FQ220972 XM_006253358 XP_006253420 NM_031355 NP_112645
|
| Function |
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion outer membrane.
|
| Tissue Specificity |
Isoform 1 is widely expressed with strong expression in atrium and ascitic tumor, lower levels in brain and very low levels in liver and kidney. Isoform 2 is also widely expressed with highest levels in brain but no expression in kidney. Also expressed in flagella of epididymal sperm. {ECO:0000269|PubMed:10998068, ECO:0000269|PubMed:19423663}.
|
| Top Pathways |
Huntington's disease, Calcium signaling pathway, HTLV-I infection, Viral carcinogenesis, cGMP-PKG signaling pathway
|